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NRFI Bets Today: Best No Run First Inning Picks for Monday, April 21

Updated April 22, 2025 | 8:02 am CDT by Sam Smith

Betting on the first inning has become one of the most exciting ways to get instant sweat on the MLB slate. Whether you’re backing elite arms to start strong or banking on explosive lineups to break through early, NRFI and YRFI bets offer real value when backed by data. We’ve analyzed today’s MLB matchups beginning to find the best NRFI bets today. Let’s get into it.

NRFI Bets Today: Best No Runs First Inning Picks

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Reds vs. Marlins | NRFI Bets Today

This matchup features two good young pitchers: Nick Lodolo for the Reds and Max Meyer for the Marlins. Lodolo enters the game with a 2-1 record and a 2.31 ERA over 23.1 innings, boasting a WHIP of 0.81. Meyer, on the other hand, has a 1-2 record with a 2.63 ERA and a WHIP of 1.13 over 24 innings.

Offensively, both teams are in the bottom half of the league in first inning run rate season. Plus, both Lodolo and Meyer have demonstrated the ability to suppress early scoring, making the NRFI bet the better option for this game.​

Best NRFI/YRFI Bet: No Runs First Inning (-125, BetMGM)


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Padres vs. Tigers | YRFI Bets Today

Keider Montero gets the ball for Detroit, and he’s coming off a rough outing where he allowed five runs and three homers. He also faced the Padres late last season and gave up another five runs. San Diego’s lineup, led by Fernando Tatis Jr., is clicking, and it currently leads MLB in both batting average and on-base percentage.

On the other side, Randy Vasquez starts for San Diego. While his ERA looks solid (1.74), it hides deeper issues like 14 walks to just 8 strikeouts over his four starts. He pitches to and has struggled with control, which is dangerous against a Tigers team that ranks top 10 in most offensive metrics and has been especially dangerous at home.

Between Vasquez’s shaky command, Montero’s home run issues and two lineups loaded with power and speed at the top, this is a clear YRFI play.

Best NRFI/YRFI Bet: Yes Runs First Inning (+100, Fanatics)

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Sam Smith

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Sam Smith

Sam Smith is a writer and editor with Stokastic and OddsShopper. He has been immersed in the world of professional sports data since 2015 while also writing extensively on the NFL for a multitude of blogs and websites. With OddsShopper, Sam looks to blend his sports and editorial expertise with OddsShopper's data to bring you the best betting information possible.

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